My research program is directed at exploring and understanding the factors that influence the emergence and persistence of emerging and re-emerging diseases at the human- wildlife-environmental interface. My program embraces a systems biology approach to ecosystem health integrated with public health, beginning within host - pathogen dynamics and extending to the livelihoods of communities living with wildlife, including the impact on ecosystem function and local communities themselves. My approach integrates critical crosscutting elements that can influence infectious disease dynamics such as culture and behavior, gender dimensions, and climate change.