Elise Miller-Hooks holds the Bill and Eleanor Hazel Endowed Chair in Infrastructure Engineering and chairs the Sid & Reva Dewberry Department of Civil, Environmental & Infrastructure Engineering at George Mason University. She is founding editor-in-chief of Sustainability Analytics and Modeling and has advised the World Bank. She was a program director at the National Science Foundation and is a former faculty member at the University of Maryland, Pennsylvania State University, and Duke University.

Her research applies operations research concepts to transportation and infrastructure, with emphasis on disaster protection and resilience. Miller-Hooks served on the U.S. Congress-initiated Transportation Resilience Metrics Committee for the National Academies of Science, Engineering, and Medicine and as chair for the 2023 Roundtable on Transport System Resilience at the Organisation for Economic Cooperation and Development's International Transport Forum.